Rat Anti-Mouse CD40-LE/AF Antibody MBS673360 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD40-LE/AF Antibody
CompanyMyBioSource.com
Price $365.00Supplier Page View Company Product Page
Catalog NumberMBS673360
Quantity0.5 mg
ApplicationsFlow Cytometry, Immunoprecipitation
Conjugate/TagUnconjugated
FormatLow Endotoxin, Azide - Free (LE/AF)
ReactivityMouse
TargetCD40
IsotypeIgG2a kappa
Clone1C10
HostRat
ImmunogenMouse CD40, Mr 45-50 kDa
CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs.^1-5 CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow, with the levels of CD40 expression increasing thereafter during B-cell maturation. Immature B cells (IgM^+IgD^lo B220^lo) express intermediate levels of CD40, whereas mature B cells (IgM^+IgD^hi B220^hi) express high levels.^4 CD40 has a central role in B cell growth and differentiation, and signalling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE.^6 The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.^2
ClonalityMonoclonal