RABBIT ANTI YEAST RAD9 MBS222775 from MyBioSource.com

Description

MBS222775 detects Saccharomyces cerevisiae Rad9, a protein involved in the DNA damage checkpoint. In S. cerevisiae this checkpoint is mainly controlled by the PI(3) kinase-like kinase (PIKK) Mec1, which is activated in response to DNA damage. Activated Mec1 hyperphosphorylates Rad9, which in turn triggers the binding of Rad53, the orthologue of mammalian Chk2. Activated Rad53 specifically targets substrates required for cell cycle arrest, gene expression and efficient DNA repair. Mutations affecting Rad9 impair checkpoint induced cell-cycle arrest and increase genomic instability. This antibody is pan reactive with both the phosphorylated and non-phosphorylated forms of this protein

Product Specs
ItemRABBIT ANTI YEAST RAD9
CompanyMyBioSource.com
Price $380.00Supplier Page View Company Product Page
Catalog NumberMBS222775
Quantity0.05 mg
ApplicationsELISA (EIA), Western Blot (WB)
ConcentrationIgG concentration 0.5mg/ml
Conjugate/TagUnconjugated
FormatPurified
Purified IgG - liquid
TargetRAD9
IsotypeIgG
Molecular Weight148,398 Da
HostRabbit
ImmunogenThis item detects Saccharomyces cerevisiae Rad9, a protein involved in the DNA damage checkpoint. In S. cerevisiae this checkpoint is mainly controlled by the PI(3) kinase-like kinase (PIKK) Mec1, which is activated in response to DNA damage. Activated Mec1 hyperphosphorylates Rad9, which in turn triggers the binding of Rad53, the orthologue of mammalian Chk2. Activated Rad53 specifically targets substrates required for cell cycle arrest, gene expression and efficient DNA repair. Mutations affecting Rad9 impair checkpoint induced cell-cycle arrest and increase genomic instability.

This antibody is pan reactive with both the phosphorylated and non-phosphorylated forms of this protein
ClonalityPolyclonal