Complement 4d (C4d) MBS438482 from MyBioSource.com

Product Specs
ItemComplement 4d (C4d)
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS438482
Quantity0.1 mg
ApplicationsImmunofluorescence (IF), Immunohistology (IH)
Conjugate/TagUnconjugated
ReactivityHuman
TargetComplement 4d
IsotypeIgG1 kappa
Molecular Weight192kDa (predicted)
CloneSPM545
HostMouse
ImmunogenThis MAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d. C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment
NCBI Full Gene Namecomplement component 4B (Chido blood group), complement component 4A (Rodgers blood group)
NCBI Gene AliasesC4AD, CH, CO4, C4S, C4B3, C4B2, C4B1, CPAMD3, C4B5, C4A6, C4A4, RG, C4A2, C4A3, C4B_2, C4F, C4BD, CPAMD2, C4B12, C4
ClonalityMonoclonal