The PSEN2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to AD4, E51, Presenilin 2, and PSEN2. This antibody recognizes Human, and Rat antigen. The PSEN2 Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified