The DSP Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Desmoplakin, Desmoplakin 1, DPI, and DSP. This antibody recognizes Human, and Mouse antigen. The DSP Polyclonal Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus