The anti-human CD272 (BTLA)-R-PE Antibody from MyBioSource.com is a Mouse Monoclonal antibody. This antibody recognizes Human antigen. The anti-human CD272 (BTLA)-R-PE Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Flow Cytometry.
Description
Information: Human CD272 (BTLA, B and T Lymphocyte Attenuator) is a member of the Immunoglobulin superfamily and has sequence homology to PD-1 and CTLA4. It is expressed on T and B lymphocytes and other hemopoetic lineages. Engagement of this molecule by its ligand, CD270(HVEM, a TNF superfamily member) can down regulate activated T and B cell responses. CD272 levels on antigen specific CD8+ T cells have been reported to decrease in viral specific, but not melanoma specific activated lines (1). Polymorphism of the CD272 molecule has been linked to rheumatoid arthritis (3). Antibody from clone ANC5A5 binds to CD272 on the cell surface of human PBMC in Flow cytometry and to recombinant CD272-muIg in EIA. This antibody does not block binding of Biotinylated CD270(HVEM)-muIg to CD272-muIg in EIA, but appears to enhance this interaction. Antibodies ANC6E9 and ANC5A5 each bind a distinct epitope of CD272 and are suitable as a matched pair for EIA using ANC6E9 as capture and Biotinylated ANC5A5 as detector