The IL10RA Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD210, IL10R, and IL10RA. This antibody recognizes Human, Mouse, and Rat antigen. The IL10RA Polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene