MyBioSource.com's MRCKB Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The MRCKB Antibody was generated using CDC42BPB as the antigen and it reacts with Human, Mouse, and Rat.
Description
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.Nakajima D., DNA Res. 9:99-106(2002).Olsen J.V., Cell 127:635-648(2006).Hirosawa M., DNA Res. 6:329-336(1999)