The Gle1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to GLE1. This antibody recognizes Human, Mouse, and Rat antigen. The Gle1 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist