The PIWI-L1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HIWI, Miwi, Piwi, and PIWIL1. This antibody recognizes Human, Mouse, and Rat antigen. The PIWI-L1 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
PIWI-L1 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L1 is thought to play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells as removing PIWI-L1 protein from single germline stem cells significantly decreases the rate of their division. Recent studies have shown that overexpression of PIWI-L1 (as well as other PIWI-like proteins) are potential biomarkers for colon and other cancers