The RAT ANTI HUMAN CD52:Low Endotoxin Antibody from MyBioSource.com is a Rat Monoclonal antibody to CD52. This antibody recognizes Human antigen. The RAT ANTI HUMAN CD52:Low Endotoxin Antibody has been shown to work in the following applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, Western Blot, and Other.
Description
Rat anti Human CD52 antibody, clone YTH34.5 reacts with the human CD52 antigen, also known as CAMPATH-1. The CD52 antigen is a remarkably small but heavily glycosylated peptide attached to the cell surface membrane via a GPI link (Xia et al. 1991). The apparent molecular mass of the native antigen on SDS-PAGE is 25-29kDa, considerably reduced following N-glycanase treatment (Rowan et al. 1998). CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable. Humanised versions of CAMPATH-1 specific antibodies are currently in clinical trials for the treatment of a range of lymphoid malignancies (Dearden et al. 2002; Pettitt et al. 2012)