MyBioSource.com's CASP3 Antibody is a Mouse monoclonal antibody. The CASP3 Antibody was generated using CASP3, and Lice as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: ELISA, and Western Blot.
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-:-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage