The RPA1 Antibody (C-term) from MyBioSource.com is a Rabbit Polyclonal antibody to MST075, Replication Protein A, replication protein A1, RF-A, Rpa, RPA1, RPA70, and Single-stranded DNA-binding protein. This antibody recognizes Human antigen. The RPA1 Antibody (C-term) has been shown to work in the following applications: ELISA, and Western Blot.
Description
RPA1 plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.
Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange