The Mouse Rnasel Antibody (N-term) from MyBioSource.com is a Rabbit Polyclonal antibody to RNase L, and RNASEL. This antibody recognizes Mouse antigen. The Mouse Rnasel Antibody (N-term) has been shown to work in the following applications: ELISA, and Western Blot.
Description
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity)