The WHSC2 Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to NELFA. This antibody recognizes Human antigen. The WHSC2 Antibody (Center) has been shown to work in the following applications: ELISA, and Western Blot.
Description
This gene is expressed ubiquitously with higher levels in
fetal than in adult tissues. It encodes a protein sharing 93%
sequence identity with the mouse protein. Wolf-Hirschhorn syndrome
(WHS) is a malformation syndrome associated with a hemizygous
deletion of the distal short arm of chromosome 4. This gene is
mapped to the 165 kb WHS critical region, and may play a role in
the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded
protein is found to be capable of reacting with HLA-A2-restricted
and tumor-specific cytotoxic T lymphocytes, suggesting a target for
use in specific immunotherapy for a large number of cancer
patients. This protein has also been shown to be a member of the
NELF (negative elongation factor) protein complex that participates
in the regulation of RNA polymerase II transcription elongation