MyBioSource.com's RASA1 Antibody (C-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The RASA1 Antibody (C-term) was generated using RASA1, and RASGAP as the antigen and it reacts with Human.
Description
The protein encoded by this gene is located in the
cytoplasm and is part of the GAP1 family of GTPase-activating
proteins. The gene product stimulates the GTPase activity of normal
RAS p21 but not its oncogenic counterpart. Acting as a suppressor
of RAS function, the protein enhances the weak intrinsic GTPase
activity of RAS proteins resulting in the inactive GDP-bound form
of RAS, thereby allowing control of cellular proliferation and
differentiation. Mutations leading to changes in the binding sites
of either protein are associated with basal cell carcinomas.
Alternative splicing results in two isoforms where the shorter
isoform, lacking the N-terminal hydrophobic region but retaining
the same activity, appears to be abundantly expressed in placental
but not adult tissues