MyBioSource.com's Phospho-Rb (S780) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Dot Blot, ELISA, and Immunohistochemistry. The Phospho-Rb (S780) Antibody was generated using p105-Rb, pRB, and RB1 as the antigen and it reacts with Human, and Rat.
Description
RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma