The PDF Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to PDF. This antibody recognizes Human antigen. The PDF Antibody (Center) has been shown to work in the following applications: ELISA, and Western Blot.
Description
Protein synthesis proceeds after formylation of methionine
by methionyl-tRNA formyl transferase (FMT) and transfer of the
charged initiator f-met tRNA to the ribosome. In eubacteria and
eukaryotic organelles the product of this gene, peptide deformylase
(PDF), removes the formyl group from the initiating methionine of
nascent peptides. In eubacteria, deformylation of nascent peptides
is required for subsequent cleavage of initiating methionines by
methionine aminopeptidase. The discovery that a natural inhibitor
of PDF, actinonin, acts as an antimicrobial agent in some bacteria
has spurred intensive research into the design of
bacterial-specific PDF inhibitors. In human cells, only
mitochondrial proteins have N-formylation of initiating
methionines. Protein inhibitors of PDF or siRNAs of PDF block the
growth of cancer cell lines but have no effect on normal cell
growth. In humans, PDF function may therefore be restricted to
rapidly growing cells