HIF1 alpha Antibody MBS438355 from MyBioSource.com

Product Specs
ItemHIF1 alpha Antibody
CompanyMyBioSource.com
Price $275.00Supplier Page View Company Product Page
Catalog NumberMBS438355
Quantity0.1 mg
ApplicationsELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IG), Functional Studies
Conjugate/TagUnconjugated
ReactivityHuman
TargetHIF1 alpha
IsotypeIgG2b kappa
Molecular Weight92-110kDa
CloneHIF1A-84
HostMouse
ImmunogenHIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions
NCBI Full Gene Namehypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
NCBI Gene AliasesHIF1, MOP1, PASD8, HIF-1A, HIF1-ALPHA, bHLHe78, HIF-1alpha
ClonalityMonoclonal