The SUMO2 Antibody (C-term) from MyBioSource.com is a Mouse Monoclonal antibody to SENTRIN-2, and SUMO2. This antibody recognizes Human, Mouse, Rat, Chicken/Bird, Hamster, Non-Human Primate, and Porcine antigen. The SUMO2 Antibody (C-term) has been shown to work in the following applications: ELISA, Immunofluorescence, and Western Blot.
Description
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins