MyBioSource.com's RANGAP1 Antibody (N-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The RANGAP1 Antibody (N-term) was generated using RanGap, and RANGAP1 as the antigen and it reacts with Human.
Description
RanGAP1, is a homodimeric 65-kD polypeptide that
specifically induces the GTPase activity of RAN, but not of RAS by
over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a
regulator molecule that keeps RAN in the active, GTP-bound state.
The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence
is unrelated to that of GTPase activators for other RAS-related
proteins, but is 88% identical to Fug1, the murine homolog of yeast
Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the
nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN
GTP/GDP cycle