Rabbit anti-Claspin Antibody, Affinity Purified A300-266A from Bethyl Laboratories, Inc.

Product Specs
ItemRabbit anti-Claspin Antibody, Affinity Purified
CompanyBethyl Laboratories, Inc.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberA300-266A
Quantity100 µg
ApplicationsWB, IP, IHC
Concentration1000 µg/ml
Conjugate/TagUnconjugated
FormatWhole IgG
ReactivityHuman
TargetClaspin
HostRabbit
Antibody TypePrimary
NCBI Full Gene Nameclaspin
ClonalityPolyclonal
IsotypeWhole IgG
Domain/Region/Terminusbetween 725 and 775
Storage2 - 8°C

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Bethyl Laboratories, Inc.

P.O. Box 850

Montgomery, Texas 77356

United States

Phone: 1-800-338-9579
Fax: 1-866-597-6105

Email: orders@fortislife.com

Company Profile

Website: fortislife.com

(1) TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitinationNucleic Acids ResearchFebruary 22, 2022Xuefei Zhu et al.Fast Mutagenesis Kit V2 (Vazyme). Antibodies and reagents Polyclonal antibodies for anti-CLASPIN (A300–266A), anti-TRIM21 (A302-519A), Anti-CHK1(A300-298A), anti-HA (A190–208A) and anti-MYC (A190–205A) were purchased

(2) Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stabilityJournal of Clinical InvestigationJune 29, 2020Reihaneh Zarrizi et al.200-002-211, Jackson ImmunoResearch Laboratories), and rabbit polyclonal anti-CtIP (1:500; catalog A300-266A, Bethyl). The proximity ligation assay (PLA) reaction (Duolink, MilliporeSigma) to detect anti-biotin

(3) The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN FunctionCell reportsDecember 10, 2019Rai R, Gu P, Broton C, Kumar-Sinha C, Chen Y, Chang S.AB_2245123" Rabbit anti-Claspin,Novus,"NB100–248, RRID: AB_2082897" Rabbit anti-Claspin,Bethyl Laboratories,"A300–266A, RRID: AB_155895" Rabbit anti phospho-RPA32 (S4/S8),Bethyl Laboratories,"A300–245A, RRID: AB_210547" Mouse anti PCNA

(4) PHF11 promotes DSB resection, ATR signaling, and HRGenes & developmentJanuary 1, 2017Gong Y, Handa N, Kowalczykowski SC, de Lange T.Abcam), RAD1 (mouse monoclonal; Abcam), Rad9 (rabbit polyclonal; Abcam), Claspin (Bethyl Laboratories, A300-266A), Mre11 (Novus, NB100-142), RAD50 (Bethyl Laboratories, A300-184A), NBS1 (Abcam, 32074), Histone H3

(5) Stem cell function and stress response are controlled by protein synthesisNatureJune 16, 2016Blanco S, Bandiera R, Popis M, Hussain S, Lombard P, Aleksic J, Sajini A, Tanna H, Cortés-Garrido R, Gkatza N, et al.9585P), anti-Snail (Abcam, ab180714), anti-SOD2 (Abcam, ab13534), anti-CLSPN (Bethyl Laboratories, A300-266A), anti-ZAK (Sigma, HPA017205), anti-CHAF1B or CAF1 p60 (Abcam, ab180371). Polyclonal α-Tubulin (Abcam,

(6) Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosisNucleic Acids ResearchDecember 1, 2014Martina Magni, Vincenzo Ruscica, Giacomo Buscemi, Ja-Eun Kim, Benjamin Tamilselvan Nachimuthu, Enrico Fontanella, Domenico Delia, Laura Zannini

(7) Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrityPLoS geneticsJanuary 1, 2013Koundrioukoff S, Carignon S, Técher H, Letessier A, Brison O, Debatisse M.goat anti-ATR (N-19) antibody (sc-1887, Santa Cruz Biotechnology, Inc.), rabbit anti-Claspin antibody (A300-266A, Bethyl Laboratories, Inc.), mouse anti-Rad17 (sc-17761, Santa Cruz Biotechnology, Inc.), rabbit anti-phospho-Rad17

(8) Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signalingPLoS pathogensJanuary 1, 2013Mohni KN, Smith S, Dee AR, Schumacher AJ, Weller SK.

(9) Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerancePloS oneJanuary 1, 2013Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, Oki E, Morita M, Maehara Y.(#2589-1, Epitomics), anti-RPA32 (#2461-1, Epitomics), anti-FancD2 (LS-B493, LS Bio), anti-Claspin (A300-266A, Bethyl) and anti-histone H3 (H9289, Sigma). Relative intensity of phosphorylation level of Chk1 (Ser345)

(10) Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNAProceedings of the National Academy of Sciences of the United States of AmericaMay 8, 2012Speroni J, Federico MB, Mansilla SF, Soria G, Gottifredi V.

(11) HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progressionCancer researchSeptember 1, 2011Izawa N, Wu W, Sato K, Nishikawa H, Kato A, Boku N, Itoh F, Ohta T.

(12) USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradationHuman molecular geneticsJune 1, 2011Guervilly JH, Renaud E, Takata M, Rosselli F.

(13) ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cellsHuman molecular geneticsMay 1, 2010Despras E, Daboussi F, Hyrien O, Marheineke K, Kannouche PL.

(14) Roles of human AND-1 in chromosome transactions in S phaseThe Journal of biological chemistryJuly 31, 2009Yoshizawa-Sugata N, Masai H.

(15) Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stressOncogeneMay 7, 2009Sun TP, Shieh SY.and #2341, Cell Signaling, Danvers, MA, USA; Ser317, A300163A, Bethyl Laboratories), anti-Claspin (A300-266A, Bethyl Laboratories), anti-phospho-Rad17 (Ser645, R0445-06, US Biological), anti-Rad9 (R90820, BD Transduction laboratories

(16) USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinThe Journal of cell biologyJanuary 12, 2009Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N.

(17) Chk1 and Claspin potentiate PCNA ubiquitinationGenes & developmentMay 1, 2008Yang XH, Shiotani B, Classon M, Zou L.

(18) Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemiaHuman molecular geneticsMarch 1, 2008Guervilly JH, Macé-Aimé G, Rosselli F.

(19) Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stressMolecular cellAugust 4, 2006Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L.

(20) Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stressMolecular cellAugust 4, 2006Mailand N, Bekker-Jensen S, Bartek J, Lukas J.

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Rabbit anti-Claspin Antibody, Affinity Purified from Bethyl Laboratories, Inc.

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Bethyl Laboratories, Inc.

Citations (21)

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Rabbit anti-Claspin Antibody, Affinity Purified from Bethyl Laboratories, Inc.

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