The LSD1 Antibody / Lysine-Specific Demethylase 1 from Biorbyt is a Rabbit Polyclonal antibody. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The LSD1 Antibody / Lysine-Specific Demethylase 1 has been shown to work in the following applications: Western Blot.
Description
LSD1 (Lysine-specific demethylase 1), also called KDM1 (lysine (K)-specific demethylase 1A), is the first histone demethylase to be identified and regulates transcription via demethylation of lysines 4 and 9 of Histone H3. It negatively regulates pro-inflammatory cytokine expression by interacting with the genes promoter region. It also plays a role in tumor development where overexpression of LSD1 correlates with a poor prognosis. It is upregulated in cancers of the bladder, breast, lung, colon, and GI tract as well as neuroblastoma and cells of mesenchymal origin such as chondrosarcoma, osteosarcoma, rhabdomyosarcoma and Ewing's sarcoma (Bennani-Baiti et al, 2012)