MyBioSource.com's ACTL6A Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ChIP, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot. The ACTL6A Polyclonal Antibody was generated using actin like 6A, ACTL6A, and BAF53 as the antigen and it reacts with Human, Mouse, and Rat.
Description
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described