The AFX, phosphorylated (Ser193) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FOXO4. This antibody recognizes Human antigen. The AFX, phosphorylated (Ser193) Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
The Forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias. Within the family, three members (FKHR, AFX and FKHRL1) have sequence similarity to the nematode homologue DAF- 16, which has been shown to mediate signaling via a pathway involving IGFR1, PI3K and Akt. There are three Akt phosphorylation sites in the FKHR proteins: Thr24, Ser256 and Ser319. Phosphorylation of FKHR family members at these sites by Akt promotes cell survival and regulates the cell cycle. Phosphorylation regulates FKHR nuclear translocation and target gene transcription