The Rabbit Anti-Neurofibromin / NF1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to neurofibromin 1, and NF1. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-Neurofibromin / NF1 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Mutations linked to neurofibromatosis type 1 led to the identification of NF1. NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the ras signal transduction pathway. In addition to type 1 neurofibromatosis, mutations in NF1 can also lead to juvenile myelomonocytic leukemia. Alternatively spliced NF1 mRNA transcripts have been isolated, although their functions, if any, remain unclear