Zonulin Antibody MBS622563 from MyBioSource.com

Description

Zonulin is a protein that participates in tight junctions between cells of the wall of the digestive tract. Initially discovered in 2000 as the target of zonula occludens toxin, secreted by cholera pathogen Vibrio cholerae, [1] it has been implicated in the pathogenesis of celiac disease [2] and diabetes mellitus type 1 [3]. It is being studied as a target for vaccine adjuvants [4]. ALBA Therapeutics is developing a zonulin receptor antagonist, AT-1001, that is currently in phase 2 clinical trials

Product Specs
ItemZonulin Antibody
CompanyMyBioSource.com
Price $415.00Supplier Page View Company Product Page
Catalog NumberMBS622563
Quantity0.02 ml
ApplicationsELISA (EL/EIA), Immunohistochemistry (IHC)
Conjugate/TagUnconjugated
FormatSupplied as a lyophilized powder. Reconstitute with 20ul sterile ddH2O
PuritySerum
Serum
ReactivityHuman
TargetZonulin
IsotypeIgG
HostRabbit; Source: Human
ImmunogenRecognizes human Zonulin
ClonalityPolyclonal

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Questions and Answers

Can this Zonulin antibody be used for studying tight junctions in the digestive tract?

Yes, the Zonulin antibody is relevant for studying tight junctions between cells of the digestive tract, as Zonulin itself is a protein that participates in these junctions. This antibody can be utilized in applications such as immunohistochemistry to visualize Zonulin expression in tissue samples.

Is this antibody suitable for research on celiac disease?

The Zonulin antibody is implicated in the pathogenesis of celiac disease, making it a suitable tool for research in this area. Researchers can use this antibody to investigate the role of Zonulin in intestinal permeability and its potential contributions to the disease.

What species does this antibody react with, and can it be used in rabbit models?

This Zonulin antibody is reactive with human samples. While it is primarily designed for human applications, it can also be used in rabbit models, as the host species for the antibody includes both human and rabbit.

How should I prepare this Zonulin antibody for use in my experiments?

The Zonulin antibody is supplied as a lyophilized powder and should be reconstituted with 20 µL of sterile double-distilled water before use. This preparation is essential to ensure optimal performance in applications such as ELISA and immunohistochemistry.