Mouse Anti-Fibrillin-UNLB MBS673084 from MyBioSource.com

Product Specs
ItemMouse Anti-Fibrillin-UNLB
CompanyMyBioSource.com
Price $340.00Supplier Page View Company Product Page
Catalog NumberMBS673084
Quantity0.2 mg
ApplicationsImmunofluorescence; Immunohistochemistry; Western Blot
Conjugate/TagUnconjugated
FormatPurified (UNLB) Antibody
TargetFibrillin
IsotypeIgG1 kappa
Clone11C1.3
HostMouse
Antibody TypeSecondary
ImmunogenHuman and bovine fibrillin (Mr 350 kDa); other species not tested
The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear.^1 In immunohistochemical staining of paraformaldehyde-fixed human skin, mAb 11C1.3 labels the elastic framework and more specifically the oxytalantic network close to the epidermis. The antibody also exhibits discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues. ^2,3 There is an aberrant expression of fibrillin in Marfan syndrome. ^4
ClonalityMonoclonal