MyBioSource.com's N-Myc Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot. The N-Myc Antibody was generated using MYCN as the antigen and it reacts with Human.
Description
N-Myc is a 49.5kD nuclear phosphoprotein that contains a basic helix-loop-helix leucine zipper domain involved in DNA binding and protein dimerization. It regulates gene expression by dimerizing with itself or other helix-loop-helix proteins and this complex binds to DNA E-box sequences of regulated genes. N-Myc is expressed in high levels during embryonic development and in the adult during B-cell differentiation. It is overexpressed in a variety of tumors, aminly neuroblastomas and is associated with rapid progression and poor prognosis