MyBioSource.com's ASIALOGLYCOPROTEIN RECEPTOR (ASGPR) is a Mouse, and Rat monoclonal antibody. The ASIALOGLYCOPROTEIN RECEPTOR (ASGPR) Antibody was generated using ASGPR, ASGPR1, ASGR, ASGR1, asialoglycoprotein receptor 1, and CLEC4H1 as the antigen. It reacts with Human, and Rat. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42kD) which mediates binding, internalisation and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i.e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediates the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed