The Rac1/cdc42, phosphorylated (Ser71) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IQGAP2. This antibody recognizes Human antigen. The Rac1/cdc42, phosphorylated (Ser71) Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Rac1 and cdc42 are members of the Rho-GTPase family. They play key roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. It has been established that GTP binding stimulates the activity of Rac1/cdc42. A putative Akt phosphorylation site at serine 71 of Rac1/cdc42 has been identified and confirmed by in vitro kinase assay (1). Phosphorylation at this site may inhibit GTP binding of Rac1, therefore attenuating the signal transduction pathway downstream of Rac1