MyBioSource.com's Integrin alpha8 (Biotin) Antibody is a Goat Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, Immunocytochemistry, and Western Blot. The Integrin alpha8 (Biotin) Antibody was generated using ITGA8 as the antigen and it reacts with Mouse.
Description
Integrin alpha 8 is a 170-200kD member of the Integrin family of adhesion molecules. It forms an exclusive noncovalent heterodimer with Integrin b1. Alpha8beta1 promotes both cell adhesion and survival and is known to bind to fibronectin, the latency-associated peptide in latent TGFb1 and nephronectin. Mouse Integrin b8 is a 1025 aa type I transmembrane glycoprotein. It contains a 969aa extracellular region (aa38-1006) and a 29aa cytoplasmic domain. One isoform may exist that shows a truncation after Ala675 of the precursor. In the ECD, mouse Integrin a8 shares 96% and 90% aa sequence identity with rat and human Integrin a8 protein, respectively