MyBioSource.com's anti-human CD252(OX40L)-R-PE is a Mouse monoclonal antibody. It reacts with Human. This antibody has been shown to work in applications such as: Block/Neutralize/Inhibit, ELISA, and Flow Cytometry.
Description
Information: Human CD252 (CD134L, OX-40L) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD252 binds to CD134 present on activated T cells, providing a costimulatory signal (1). This pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (4). Blockade of this interaction in mouse abrogated immunological effects in several models of inflammation and rejection (5,6,7,8). Antibody from clone ANC10G1 binds to CD252 on the cell surface of HUVEC in Flow cytometry, and blocks binding of recombinant CD134-muIg