b-Amyloid Precursor Protein Antibody MBS611612 from MyBioSource.com

Description

Senile plaques and neurofibrillary tangles in brain are hallmarks of Alzheimer's disease. Mutations in the beta-amyloid precursor protein (beta-APP) are contributory factors to Familial Alzheimer's Disease. The primary constituent of senile plaques are deposits of the 4 kD amyloid beta-peptide, derived from amyloid beta-precursor proteins by internal proteolysis. The

Product Specs
Itemb-Amyloid Precursor Protein Antibody
CompanyMyBioSource.com
Price $755.00Supplier Page View Company Product Page
Catalog NumberMBS611612
Concentration0.25 mg/ml
IsotypeIgG
ReactivityHuman (Hu)
ClonalityPolyclonal
ApplicationsWB, ELISA, IF, IP
ImmunogenThis antibody can be used to specifically detect the beta-amyloid precursor protein. The antibody reacts with full-length (APP695, 751, 770) and N-terminal truncated forms of beta-APP. The antibody can also be used to detect the C-terminal membrane-anchored fragment of beta-APP that remains after alpha- or beta-secretase cleavage. This antibody does not detect the beta-APP product N-terminal to the gamma-secretase cleavage site. To the best of our knowledge, reliable immunodetection of this fragment, with any antibody, has not been reported in the literature. Reactivity with this antibody has been confirmed for human, mouse, pig, and rat. Based on sequence homology (see above) reactivity with other species, including monkey, guinea pig, and chicken beta-APP is highly likely. Zymed's CT695 antibody has demonstrated superiority in detecting axonal damage
HostRabbit
Targetb-Amyloid Precursor Protein
PurityAffinity Purified
Purified by immunoaffinity chromatography
FormatSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide
Conjugate/TagUnconjugated
Quantity0.05 mg