The ESPL1 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ESPL1, SEPA, and Separase. This antibody recognizes Human, Mouse, and Rat antigen. The ESPL1 Polyclonal Antibody has been shown to work in the following applications: ELISA, and Immunohistochemistry.
Description
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids