The Anti-Human Synaptotagmin-1, Purified, (Polyclonal) (Rabbit IgG) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Syt 1, and SYT1. This antibody recognizes Human antigen. The Anti-Human Synaptotagmin-1, Purified, (Polyclonal) (Rabbit IgG) Antibody has been shown to work in the following applications: Western Blot.
Description
Synaptotagmin-1 is a synaptic vesicle membrane protein that belongs to the Synaptotagmins family; characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2-domains. Synaptotagmin-1, the first synaptotagmin studied, is an abundant synaptic vesicle protein that binds Ca2+ and phospholipids via both of its C2 domains and is essential for fast Ca2+- triggered neurotransmitter release. Multiple members (15) exist within the Synaptotagmins family with high homology in their C-terminal repeats and lowest in their N-terminal intravesicular sequences. The two internal repeats in synaptotagmin are homologous to the regulatory region of protein kinase C. Synaptotagmin -1 and 2 are highly homologous but differentially distributed, with Synaptotagmin-1 being highly expressed in the forebrain and some endocrine tissues and Synaptotagmin-2 in the brain stem and spinal cord