APC anti-human CD4 357408 from BioLegend

Product Specs
ItemAPC anti-human CD4
CompanyBioLegend
Price $166.00Supplier Page View Company Product Page
Catalog Number357408
Quantity100 tests
ApplicationsFC - Quality tested
Conjugate/TagAPC
FormatPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
ReactivityHuman
IsotypeRat IgG2b, kappa
CloneA161A1
HostRat
Antibody TypePrimary
ImmunogenHuman CD4 T cells
NCBI Full Gene NameCD4 molecule
NCBI Gene AliasesCD4mut, IMD79, Leu-3, OKT4D, T4
ClonalityMonoclonal
TargetCD4
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

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BioLegend

8999 BioLegend Way

San Diego, California 92121

United States

Phone: 1-877-246-5343 Toll-Free, USA & Canada
1-858-768-5800 International
Fax: 1-877-455-9587

Company Profile

Website: biolegend.com

(1) Collagen-Bearing Exosomes from Breast Cancer–Associated Fibroblasts Promote T-cell DysfunctionCancer Res CommunMarch 1, 2026Samir Jana, Matthew Lawton, Pin-Ji Lei, Harold Hui, Andrew Emili, Dennis JonesCD8a-APC antibody (BioLegend, cat. #300911, RRID: AB_314115) and CD4-APC antibodies (BioLegend, cat. #357407, RRID: AB_2565659). The cells were stained for 20 minutes at room temperature, rinsed twice, and analyzed

(2) Collagen-bearing exosomes from breast cancer-associated fibroblasts promote T cell dysfunctionCancer Research CommunicationsMarch 1, 2026Samir Jana, Matthew Lawton, Pin-Ji Lei, Harold Hui, Andrew Emili, Dennis JonesCD8a-APC antibody (BioLegend, cat. #300911, RRID: AB_314115) and CD4-APC antibodies (BioLegend, cat. #357407, RRID: AB_2565659). The cells were stained for 20 minutes at room temperature, rinsed twice, and analyzed

(3) Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistenceCell SystemsMay 21, 2025Caleb R. Perez, Andrea Garmilla, Avlant Nilsson, Hratch M. Baghdassarian, Khloe S. Gordon, Louise G. Lima, Blake E. Smith, Marcela V. Maus, Douglas A. Lauffenburger, Michael E. BirnbaumBrilliant Violet 421™ anti-human CD3 Antibody,Biolegend,Cat#300434; RRID:AB_10962690 APC anti-human CD4 Antibody,Biolegend,Cat#357408; RRID:AB_2565660 Alexa Fluor® 700 anti-human CD8 Antibody,Biolegend,Cat#344724; RRID:AB_2562790 PE anti-human CD45

(4) Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinomaMolecular CellApril 3, 2025John L. Pulice, Matthew Meyerson(TAPA-1) Antibody,Biolegend,CAT#349509; RRID:AB_2564020 APC anti-human CD4 Antibody,Biolegend,CAT#357408; RRID:AB_2565660 Bacterial and virus strains,Bacterial and virus strains,Bacterial and virus strains One Shot Stbl3 Chemically Competent E. coli

(5) Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genesNature biomedical engineeringJanuary 1, 2025Yin JA, Frick L, Scheidmann MC, Liu T, Trevisan C, Dhingra A, Spinelli A, Wu Y, Yao L, Vena DL, et al.temperature. Afterwards, APC-conjugated antibodies to human CD2 (BioLegend 300214), CD4 (BioLegend 357408) or CD200 (BioLegend 329208) were added and incubated on ice for 15–20 min in the dark. After 20 min,

(6) T-Cell Subpopulations and Differentiation Bias in Diabetic and Non-Diabetic Patients with Chronic Kidney DiseaseBiomedicinesDecember 24, 2024Ana Cecilia Granda Alacote, Gabriela Goyoneche Linares, María Gracia Castañeda Torrico, Daysi Zulema Diaz-Obregón, Michael Bryant Castro Núñez, Alexis Germán Murillo Carrasco, Cesar Liendo Liendo, Katherine Susan Rufasto Goche, Víctor Arrunátegui Correa, Joel de León Delgado(catalog number 317334, Biolegend®, San Diego, CA, USA), and APC-conjugated anti-CD4 (catalog number 357407, Biolegend®, San Diego, CA, USA). For Tregs, PBMCs were stained with FITC-conjugated anti-CD4 (catalog

(7) Inhibition of Bruton’s tyrosine kinase with PD-1 blockade modulates T cell activation in solid tumorsJCI InsightNovember 8, 2024Emily Schwarz, Brooke Benner, Robert Wesolowski, Dionisia Quiroga, Logan Good, Steven H. Sun, Himanshu Savardekar, Jianying Li, Kyeong Joo Jung, Megan C. Duggan, et al.were controls. After 72 hours, proliferation was assessed by flow cytometry. APC anti-CD4 (BioLegend, 357407) and PE-Cy7 anti-CD8 (BioLegend, 344711) antibodies were used to identify T cell subsets. TCR analysis. VDJ

(8) A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitopeMobile DNAOctober 9, 2024Erin E. Grundy, Lauren C. Shaw, Loretta Wang, Abigail V. Lee, James Castro Argueta, Daniel J. Powell, Mario Ostrowski, R. Brad Jones, C. Russell Y. Cruz, Heather Gordish-Dressman, et al.cells CD45,Surface,BV640,Biolegend,304044,2.5 CD3,Surface,PerCP/Cy5.5,Biolegend,300328,0.625 CD4,Surface,APC,Biolegend,357407,2.5 CD8,Surface,BV785,Biolegend,301046,1.25 CD19,Surface,APC/Cy7,Biolegend,363010,1.25 CD16,Surface,FITC,BD,560996,4 CD56,Surface,BV605,Biolegend,318334,2 HLA-A*03,Surface,PE,Invitrogen,12–5754-42,0.625 IFN-γ,Intracellular,APC,Biolegend,502512,5 IFN-γ,Intracellular,PE/Cy7,Biolegend,502527,5 TNF-α,Intracellular,BV421,Biolegend,502932,2.5 Surface

(9) A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responsesNature immunologyAugust 1, 2024Chupp DP, Rivera CE, Zhou Y, Xu Y, Ramsey PS, Xu Z, Zan H, Casali P.(clone OKT3, 63003741, eBioscience; 1:100 dilution), APC-anti-huCD4 monoclonal antibody (clone A161A1, 357407, BioLegend; 1:100 dilution), BV421-anti-huCD4 monoclonal antibody (clone A161A1, 357423, BioLegend;

(10) Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancerCell Stem CellJune 6, 2024Zahir Shah, Lei Tian, Zhixin Li, Lewei Jin, Jianying Zhang, Zhenlong Li, Tasha Barr, Hejun Tang, Mingye Feng, Michael A. Caligiuri, et al.FITC anti-human CD56 (NCAM) Antibody,BioLegend,"Cat# 362546, RRID:AB_2565964" APC anti-human CD4 Antibody,BioLegend,"Cat# 357408, RRID:AB_2565660" "FITC anti-human HLA-DR, DP, DQ Antibody",BioLegend,"Cat# 361705, RRID:AB_2563191" PE

(11) The miR-641-STIM1 and SATB1 axes play important roles in the regulation of the Th17/Treg balance in ITPScientific ReportsMay 16, 2024Hongkai Zhu, Xueqin Ruan, Kexin Zhao, Wenyong Kuang, Sufang Liu, Wenzhe Yan, Xianming Fu, Zhao Cheng, Ruijuan Li, Hongling Pengcorresponding antibodies were added. Human T cells were labeled with APC-conjugated anti-humanCD4 (357407, Biolegend), PE/CY7-conjugated anti-human IL-17a (512315, Biolegend) for Th17 cells, and APC-conjugated

(12) Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancerJournal of translational medicineApril 18, 2024Guo J, Zeng X, Zhu Y, Yang D, Zhao X.T cell transfection rates, with the following primary antibodies used: CD4 antibody (BioLegend Cat# 357408, USA), CD8 antibody (BioLegend Cat# 344714), CD45RO antibody (BioLegend Cat# 304206), CCR7 antibody

(13) HMGB1 regulates Th17 cell differentiation and function in patients with psoriasisImmunity, Inflammation and DiseaseFebruary 27, 2024Xiaofeng Zhu, Yue Dou, Yawen Lin, Gaoping Chu, Jing Wang, Lei Maenvironment for 4 h. Then, cells were stained with APC‐labeled anti‐CD4 antibody (0.8 μg/mL, cat. no. 357408; BioLegend Inc.) in the dark at room temperature for 30 min. After surface staining, the cells were

(14) Th2 cell activation in chronic liver disease is driven by local IL-33 and contributes to IL-13 dependent fibrogenesisCellular and Molecular Gastroenterology and HepatologyJanuary 1, 2024Johanna Reißing, Marie Berres, Pavel Strnad, Alexander Wree, Maria Eugenia Inzaugarat, Christian Trautwein, Tony Bruns, Henning Wolfgang ZimmermannTarget,Conjugation,Company,Catalog no. Anti-human CD4,APC,BioLegend,357407 Anti-human CD4,FITC,BD,561005 Anti-human CD4,PE,BD,561843 Anti-human CD25,FITC,BioLegend,302603 Anti-human

(15) Optimization of Cas12a for multiplexed genome-scale transcriptional activationCell GenomSeptember 13, 2023Griffith AL, Zheng F, McGee AV, Miller NW, Szegletes ZM, Reint G, Gademann F, Nwolah I, Hegde M, Liu YV, et al.prepare samples for visualization, cells were stained with APC anti-human CD4 Antibody (Biolegend, 357408), diluted 1:100 for 20–30 min on ice. Cells were washed with PBS two times to remove residual antibody

(16) SECTM1-based CAR T cells enriched with CD7-low/negative subsets exhibit efficacy in CD7-positive malignanciesBlood AdvancesJuly 11, 2023Wenwen Wei, Haiyan Ma, Dong Yang, Bin Sun, Jie Tang, Yongjie Zhu, Xinchuan Chen, Xiaoou Huang, Jiazhuo Liu, Zhengfei Hu, et al.antibodies were used: CD7 antibody (BioLegend catalogue# 343104; CA), CD4 antibody (BioLegend catalogue# 357408), CD8 antibody (BioLegend catalogue# 344714), CD45RO antibody (BioLegend catalogue# 304206), CCR7 antibody

(17) In chronic lymphocytic leukemia, activation of the thrombopoietin receptor promotes T-cell inhibitory properties, contributing to immunosuppressionEuropean journal of haematologyApril 1, 2023Ringelstein-Harlev S, Fanadka M, Horowitz NA, Bettman NP, Katz T.

(18) CD8(+) Regulatory T Cell Deficiency in Elderly-Onset Rheumatoid ArthritisJournal of clinical medicineMarch 17, 2023Watanabe R, Kadoba K, Tamamoto A, Murata K, Murakami K, Onizawa H, Fujii T, Onishi A, Tanaka M, Ito H, et al.have previously been described [30]. APC-conjugated anti-human CD4 antibody (Clone A161A1, Catalog No. 357408), PerCP-conjugated anti-human CD8 antibody (Clone SK1, Catalog No. 344708), and FITC-conjugated anti-human

(19) M1 macrophages may be effective adjuvants for promoting Th‑17 differentiation in HBeAg positive hepatitis patients with ALT ≤2ULNMolecular medicine reportsMarch 1, 2023Sun L, Yu J, Zhang N, Wang Y, Qi J.BioLegend, Inc.) incubated at 4°C for 20 min in the dark and APC-conjugated antihuman CD4 antibody (1:20; cat. no. 357407; BioLegend, Inc.) incubated at 4°C for 20 min in the dark. For intracellular staining, the cells were

(20) A Novel Anti-B7-H3 × Anti-CD3 Bispecific Antibody with Potent Antitumor ActivityLife (Basel, Switzerland)January 21, 2022Feng Y, Xie K, Yin Y, Li B, Pi C, Xu X, Huang T, Zhang J, Wang B, Gu H, et al.collected and stained with detection antibodies. Part of cells were stained with APC-anti-human CD4 (357408, BioLegend, San Diego, CA, USA), PC5.5-anti-human CD8 (344710, BioLegend, San Diego, CA, USA), and PE-anti-human CD69

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APC anti-human CD4 from BioLegend

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APC anti-human CD4 from BioLegend

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