MyBioSource.com's Rabbit Anti-HUWE1 / ARFBP1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Rabbit Anti-HUWE1 / ARFBP1 Antibody was generated using HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, and HUWE1 as the antigen and it reacts with Human, Mouse, and Rat.
Description
HUWE1 is a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed