The Amyloidβ (N3pE) Anti-Human Rabbit IgG Affinity Purify Antibody from IBL- America is a Rabbit Polyclonal antibody. This antibody recognizes Homo Sapiens, and Human antigen. The Amyloidβ (N3pE) Anti-Human Rabbit IgG Affinity Purify Antibody has been shown to work in the following applications: Immunohistochemistry, and Western Blot.
Description
Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid (Aβ) peptide, a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by β-secretase and γ-secretase. Increased release of Aβ42 or Aβ43, both of which exhibit a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, ApoE alleles or may involve other undiscovered factors. Many researchers theorize that it is this increased release of Aβ42/Aβ43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals. It is reported that a distinct Aβ peptide, Aβ (N3pE), is deposited in senile plaques in a dominant and differential manner as compared with the standard Aβ peptide