The WNT5 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Wnt family member 5B, and WNT5B. This antibody recognizes Human, Mouse, and Rat antigen. The WNT5 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
WNT5A and WNT5B are near-identical members of the WNT gene family, which consists of structurally related genes which encode secreted signaling proteins that have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis (1,2). WNT5A and WNT5B coordinate chondrocyte proliferation and differentiation by differentially regulating cyclin D1 and p130 expression, as well as chondrocyte-specific Col2a1 expression (3). Up-regulation of WNT5A and WNT5B has been observed in several types of human cancers, suggesting that they may be useful as diagnostic markers or potent therapeutic targets (4)