The Rabbit Polyclonal to Human NR1I3 / CAR Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NR1I3. This antibody recognizes Human antigen. The Rabbit Polyclonal to Human NR1I3 / CAR Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Constitutive androstane receptor (CAR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect steroid homeostasis by mediating the expression of CYP genes to xenochemicals, steroids, and lipids. CAR activity is suppressed upon ligand binding; however, the suppression is reversed by phenobarbital. CAR binds to the DR5 hormone response element as a heterodimer (with retinoid X receptor) and can activate genes in the absence of retinoids, rexinoids, or exogenous ligands