MyBioSource.com's Rabbit Anti-RELA / NFKB p65 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, Super Shift Assay, and Western Blot. The Rabbit Anti-RELA / NFKB p65 Antibody was generated using RELA as the antigen and it reacts with Human, Mouse, and Rat.
Description
NFKB1 or NFKB2 bind to REL, RELA, or RELB to form the NFKB complex. The NFKB1/RELA heterodimer is the most abundant form of NFKB. The NFKB complex is inactivated by I-kappa-B proteins that keep it trapped in the cytoplasm. Phosphorylation of serine residues on the I-kappa B proteins mark them for ubiquitination and destruction, and NFKB translocates to the nucleus where it binds DNA