The Rabbit Anti-GALR1 / Galanin Receptor 1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Galanin Receptor 1, and GALR1. This antibody recognizes Human, and Non-Human Primate antigen. The Rabbit Anti-GALR1 / Galanin Receptor 1 Antibody has been shown to work in the following applications: Immunocytochemistry, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
GalR1 is a Galanin Receptor that mediates the effects of the peptide galanin in a wide variety of tissues. Unlike GalR2, the primary signaling mechanism of GalR1 is by inhibiting adenylate cyclase through Gi. GalR1 regulates the GnRH neuroendocrine axis with its expression in POMC neurons. Pathogens like E Coli can cause diarrhea by increasing expression of Galanin Receptor 1 in the epithelial cells lining the colon, resulting in increased secretion of colonocyte chloride and fluid