The OGDH Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to 2-Oxoglutarate Dehydrogenase E1 Component, AKGDH, OGDC, OGDH, and oxoglutarate dehydrogenase. This antibody recognizes Human, Mouse, and Rat antigen. The OGDH Polyclonal Antibody has been shown to work in the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms