Fig 2: Association between the expression level of common DEGs and immune cell infiltration. The relationship between expression levels of (a) SATB-2, (b) ORP-1, (c) MYB, and (d) CDX-2 and tumor purity, infiltrating B cells, CD4+ T cells, CD8+ T cells, and macrophages was investigated by the online tool Tumor Immune Estimation Resource Version. DEGs: Differentially expressed genes. TIMER: Tumor Immune Estimation Resource Version

Fig 3: Relationship between core DEGs and tumor-infiltrating immune cell markers in CRC. a The representative immunohistochemical staining images of SATB-2, ORP-1, MYB, CDX-2, CD19, CD4, CD8, and CD68. b Spearman analysis results indicated that core DEGs were positively associated with tumor-infiltrating immune cell markers. DEGs: Differentially expressed genes. CRC: Colorectal cancer

Fig 4: Comparison of the expression levels of core DEGs in GSE56386. a SATB-2, c MYB, d CDX-2, e SLC26A3, and g FAR2 were significantly downregulated and (l)AKR1B10 was apparently upregulated among cetuximab non-responders compared with cetuximab responders. No significant differences were seen in (b)ORP-1, f EPHB2, h VAV3, i ATP10B, j ADH1A, k ADH1C. DEGs: Differentially expressed genes