Caspase-1 (D7F10) Rabbit mAb from Cell Signaling Technology

Yes, the Caspase-1 (D7F10) Rabbit mAb has been utilized in studies investigating NLRP3 inflammasome activation, as it detects cleaved Caspase-1, which is a key component in the inflammasome pathway. For instance, it was referenced in research showing that enteropathogenic Escherichia coli induces rapid activation of the NLRP3-caspase-1 inflammasome in human macrophages (goddard2019).

The Caspase-1 (D7F10) Rabbit mAb has been shown to work effectively in Western blotting applications, as evidenced by its use in various studies to detect cleaved Caspase-1 in different experimental setups, including those examining the effects of oxidative stress and inflammasome activation (li2021, wang2024).

This antibody has been cited in applications such as Western blotting and immunoprecipitation. It has been used to study the role of Caspase-1 in various contexts, including inflammation and cell death mechanisms, as seen in studies related to NLRP3 inflammasome activation and pyroptosis (heiser2021, sun2022).

Yes, the Caspase-1 (D7F10) Rabbit mAb has been referenced in studies examining oxidative stress, particularly in the context of NLRP3 inflammasome activation. For example, it was used to assess the effects of methylglyoxal-induced oxidative stress on endothelial cells, highlighting its relevance in inflammatory responses (wang2024).