C3aR (D-12) Antibody sc-133172 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemC3aR (D-12) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-133172
Antibody TypePrimary Antibodies
NCBI Gene AliasesC3AR, HNFAG09, AZ3B
CloneD-12
Quantity200 µg/ml
ApplicationsWB, IP, IF, ELISA
FormatPurified
Conjugate/TagUnconjugated
Hostmouse
Reactivitymouse, rat, human
ClonalityMonoclonal
NCBI Full Gene Namecomplement component 3a receptor 1, complement C3a receptor 1
TargetC3aR
IsotypeIgG2a

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Pharmacological targeting of C3aR modulates mesangial matrix deposition in db/db micePeerJApril 28, 2026Jing Zheng, Xiaoting Wu, Mengjie Weng, Jianxin Wan, Xiaohong Zhangwere used: Complement C3 (1:500, sc-28294; Santa Cruz Biotechnology, Dallas, TX, USA), C3aR (1:5,000, sc-133172; Santa Cruz Biotechnology, Dallas, TX, USA), Fibronectin (1:200, ab24130; Abcam, Cambridge, UK), Osteopontin

(2) Immune Predictors of Radiotherapy Outcomes in Cervical CancerAdvanced ScienceMarch 1, 2026Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen(CST, 9662; 1:1000), C3(Santa Cruz Biotechnology, sc‐28294; 1:100), C3aR (Santa Cruz Biotechnology, sc‐133172; 1:200), CD68(Abcam, ab303565; 1:200) overnight at 4°C. After washing with PBS‐T (0.1% Tween‐20), IF

(3) The C3-C3aR axis drives rotenone-induced cognitive damage via synaptic engulfment, dark microglia and PANoptosisRedox BiologyJanuary 30, 2026Jianing Liu, Liyan Hou, Yu Ma, Lu Tian, Jau-Shyong Hong, Jie Zhao, Qingshan Wangphosphorylated-RIP3 (ab95117) from Abcam (Waltham, MA, UK); C3aR and Iba-1 antibodies from Santa Cruz Biotechnology (sc-133172, Dallas, TX, USA) and Wako Chemicals (019–19741, Tokyo, Japan), respectively; GFAP (16825), Bcl2 (68103),

(4) Targeting central immune signaling enhances the effects of methylphenidate in alleviating apathy-like behavior in 5xFAD miceResearchSquareDecember 4, 2025Raisa Monteiro, Jeffrey T. Dunn, Guadalupe Rodriguez, Daniel W. Fisher, Hongxin Dongantibodies and dilutions utilized for this study were C3 (1:50, sc-28294, Santa Cruz Biotech), C3ar (1:100, sc-133172, Santa Cruz Biotech), Drd1 (1:200, NBP2–16213, Novus Biologicals), and Drd2 (1:100, sc-5303, Santa Cruz

(5) Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changesMolecular PsychiatryJuly 10, 2025Ashutosh Tripathi, Alona Bartosh, Dania Jose, Jocelyn Mata, Usama Hussein, Fernanda Laezza, Zhongming Zhao, Anilkumar Pillaiantibodies, CD11b (#101228), CD45 (#103138), Ly6C (#128022) (all purchased from BioLegend) and C3aR (# sc-133172, Santa Cruz Biotechnology). Cells were washed with cold PBS and fixed with Fixation/Permeabilization

(6) C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasisMol MetabApril 4, 2025Renan Pereira de Lima, Ang Li, Ankit Gilani, Alfonso Rubio-Navarro, Charles D. Warren, Isabella Y. Kong, Jacob B. Geri, James C. Lofrom Cell Signaling, anti-pMAPK6/Erk3 (ab74032) and anti-COX4 (ab14744) were from Abcam, anti C3aR1 (sc-133172) was from Santa Cruz. Detection of proteins was carried out by incubations with HRP-conjugated secondary

(7) An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertensionJCI InsightFebruary 13, 2025Ram Raj Prasad, Sushil Kumar, Hui Zhang, Min Li, Cheng-Jun Hu, Suzette Riddle, Brittany A. McKeon, M.G. Frid, Konrad Hoetzenecker, Slaven Crnkovic, et al.MBS9203258; Thermo Fisher Scientific, PA5-79034), anti-C3aR1, 1:1,000 (Santa Cruz Biotechnology Inc., sc-133172), anti-H3, 1:2,000 (Cell Signaling Technology, 9715S), anti–α-tubulin, 1:5,000 (MilliporeSigma, T6199),

(8) Systematic characterization of multi-omics landscape between gut microbial metabolites and GPCRome in Alzheimer’s diseaseCell ReportsMay 28, 2024Yunguang Qiu, Yuan Hou, Dhruv Gohel, Yadi Zhou, Jielin Xu, Marina Bykova, Yuxin Yang, James B. Leverenz, Andrew A. Pieper, Ruth Nussinov, et al.GAPDH (D4C6R) Mouse mAb,Cell Signaling Technology,Cat#97166; RRID: AB_2756824 C3AR Antibody (D-12),Santa Cruz,Cat#sc-133172; RRID: AB_2066736 ,, Biological samples,, ,, N-PER™ Neuronal Protein Extraction Reagent,Thermo Scientific,Cat#

(9) Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregationBMC biologyDecember 8, 2023Yang Y, Zhao C, Chen B, Yu X, Zhou Y, Ni D, Zhang X, Zhang J, Ling X, Zhang Z, et al.phalloidin (A12379, ThermoFisher), anti-α-tubulin antibody (GTX76511, GeneTex), and C3aR antibody (Sc-133172, Santa Cruz Biotechnology, Inc; or Abnova, H00010454‐PW1). The specificity of C3aR primary antibody

(10) Deciphering the Role of the Anaphylatoxin C3a: A Key Function in Modulating the Tumor MicroenvironmentCancersMay 30, 2023Hanna J, Ah-Pine F, Boina C, Bedoui Y, Gasque P, Septembre-Malaterre A.

(11) Complement Activation and Up-Regulated Expression of Anaphylatoxin C3a/C3aR in Glioblastoma: Deciphering the Links with TGF-β and VEGFCancersMay 7, 2023Ah-Pine F, Malaterre-Septembre A, Bedoui Y, Khettab M, Neal JW, Freppel S, Gasque P.PA5109467, Ref 17107403, Fischer Sci., Hampton, NH, USA, 1:100) or C3aR (mouse antibody clone D12, ref SC133172, Santa Cruz, 1:100) and VEGF (rabbit antibody Millipore, Burlington, MA, USA, AB1442, 1:100), or C3aR

(12) Macrophages promote heat stress nephropathy in mice via the C3a-C3aR-TNF pathwayImmunobiologyMarch 1, 2023Yang Y, Zhang D, Song M, Wang C, Lv J, Zhou J, Chen M, Ma L, Mei C.

(13) Phospholipase A(2) induces acute kidney injury by complement mediated mitochondrial apoptosis via TNF-α/NF-κB signaling pathwayFood and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationFebruary 1, 2023Tang X, Wei T, Guan M, Li P, Pu Y, Cheng L, Zhou Z, Fu P, Zhang L.

(14) C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasomeLife sciencesNovember 1, 2022You D, Weng M, Wu X, Nie K, Cui J, Chen Y, Yang L, Wan J.

(15) Complement Is Required for Microbe-Driven Induction of Th17 and PeriodontitisJournal of immunology (Baltimore, Md. : 1950)October 1, 2022Wang H, Ideguchi H, Kajikawa T, Mastellos DC, Lambris JD, Hajishengallis G.quantitative real-time PCR using 16S rRNA gene primers (20, 31). Antibodies MAb to C3a receptor (C3aR) (cat# sc-133172, clone D-12, IgG2a, κ, 1:50) was purchased from Santa Cruz Biotechnology, Dallas, TX. MAbs against mouse

(16) Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous NephropathyJournal of the American Society of Nephrology : JASNSeptember 1, 2022Gao S, Cui Z, Zhao MH.

(17) Gypenoside XVII, an Active Ingredient from Gynostemma Pentaphyllum, Inhibits C3aR-Associated Synaptic Pruning in Stressed MiceNutrientsJune 10, 2022Zhang MM, Huo GM, Cheng J, Zhang QP, Li NZ, Guo MX, Liu Q, Xu GH, Zhu JX, Li CF, et al.(ab227805) and Iba1 (ab5076) were purchased from Abcam (Cambridge, MA, USA). The antibody for C3aR (sc-133172) was purchased from Santa Cruz (Freemont, CA, USA). 2.3. Drug Administration Firstly, in order to

(18) C-reactive protein inhibits C3a/C3aR-dependent podocyte autophagy in favor of diabetic kidney diseaseFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJune 1, 2022Zhang L, Li W, Gong M, Zhang Z, Xue X, Mao J, Zhang H, Li S, Liu X, Wu F, et al.

(19) Characterization of Mast Cells from Healthy and Varicose Human Saphenous VeinBiomedicinesMay 3, 2022Callesen KT, Mogren S, Berlin F, Andersson C, Schmidt S, Klitfod L, Esteban V, Poulsen LK, Jensen BM.(monoclonal),1:100/1:1000,MAB1222,Chemicon Mouse anti-chymase (monoclonal),1:100,MA5-11717,Thermo Fisher Sci Mouse anti-C3aR (monoclonal),1:50,sc-133172,Santa Cruz Biotechnology Mouse anti-FcεRI (monoclonal),1:50,LS-B4054,LSBio Rabbit anti-PTAFR (polyclonal),1:50,HPA027543,Sigma-Aldrich Rabbit

(20) C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse ModelsCancer immunology researchFebruary 1, 2022Nandagopal S, Li CG, Xu Y, Sodji QH, Graves EE, Giaccia AJ.immunoprecipitation protocol was followed as described in a previous publication (25). 1 μg of anti-human C3aR (Cat# SC-133172, Santa Cruz Biotechnology) and 1 μg of anti-human CD11a (Cat# 350602, Biolegend) were used in 1 mg of

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C3aR (D-12) Antibody

C3aR (D-12) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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C3aR (D-12) Antibody from Santa Cruz Biotechnology, Inc.

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