PP2C-alpha (D18C10) XP ® Rabbit mAb 3549S from Cell Signaling Technology

Product Specs
ItemPP2C-alpha (D18C10) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number3549S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC, FC-FP
ReactivityH, Mk
TargetPP2C alpha
HostRabbit
NCBI Gene AliasesPP2C-ALPHA, PP2CA, PP2Calpha
ClonalityMonoclonal
NCBI Full Gene Nameprotein phosphatase, Mg2+/Mn2+ dependent 1A
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD18C10
Molecular Weight43

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Cell Signaling Technology

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Phone: 978-867-2388
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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhageScience advancesSeptember 30, 2022Feng D, Zhou J, Liu H, Wu X, Li F, Zhao J, Zhang Y, Wang L, Chao M, Wang Q, et al.Proteintech, 51064-2), anti-NDRG2 (1:100; Abcam, ab174850), and anti-PPM1A (1:100; Cell Signaling Technology, 3549). After incubation for 4 hours at 4°C, the protein A/G magnetic beads (MedChemExpress, HY-K0202) were

(2) Limonin, an AMPK Activator, Inhibits Hepatic Lipid Accumulation in High Fat Diet Fed MiceFrontiers in PharmacologyJanuary 24, 2022Si-wei Wang, Tian Lan, Hang-fei Chen, Hao Sheng, Chun-yi Xu, Li-feng Xu, Fang Zheng, Feng ZhangCell Signaling Technology), CAMKK2 (#16810, Cell Signaling Technology), PP2A (#2038, Cell Signaling Technology), PP2C (#3549, Cell Signaling Technology), phospho-TAK1 (#4508, Cell Signaling Technology), TAK1 (#5206, Cell Signaling Technology

(3) Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1Scientific ReportsDecember 1, 2021Arunabh Choudhury, Taj Mohammad, Nikhil Samarth, Afzal Hussain, Md. Tabish Rehman, Asimul Islam, Mohamed F. Alajmi, Shailza Singh, Md. Imtaiyaz Hassanpromotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549 (2012). 17. Carrino, S., Hennecker, C. D., Murrieta, A. C. & Mittermaier, A. Frustrated folding of guanine

(4) Telomere Replication: Solving Multiple End Replication ProblemsFrontiers in Cell and Developmental BiologyApril 1, 2021Erin Bonnell, Emeline Pasquier, Raymund J. Wellingerpromotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549. doi: 10.1038/ emboj.2012.215 Stroik, S., and Hendrickson, E. A. (2020a). Telomere fusions and translocations:

(5) Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organizationNature Reviews Molecular Cell BiologyApril 1, 2021Ci Ji Lim, Thomas R. Cechpromotes telomere duplex replication and general replication restart after fork stalling. EMBO J 31, 3537–3549 (2012). [PubMed: 22863775] 124. Zhang M et al. Mammalian CST averts replication failure by preventing

(6) Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the AgingBiology (Basel)March 24, 2021Graciela Gavia-García, Juana Rosado-Pérez, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez, Edelmiro Santiago-Osorio, Víctor Manuel Mendoza-Núñeztelomere duplex replication and general replication restart after fork stalling. EMBO J. 2012, 31, 3537–3549. [CrossRef] [PubMed] Grossi, S.; Puglisi, A.; Dmitriev, P.V.; Lopes, M.; Shore, D. Pol12, the B subunit

(7) A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistanceNature chemical biologyMarch 1, 2021Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, et al.(#4150), Ubiquitin (#3936), Skp1 (#12248), phospho-ACC Ser79 (#11818), ACC (#3676), Lkb1 (#3047), PP2Cα (#3549), phospho-MFF Ser146 (#49281), phospho-Raptor Ser792 (#2083), Raptor (#2280), pS6 Ser235/236 (#4858),

(8) The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regenerationPLoS biologyFebruary 1, 2021Zhou R, Wu Q, Wang M, Irani S, Li X, Zhang Q, Meng F, Liu S, Zhang F, Wu L, et al.1:1,000 dilution), anti-pTBK1 (S172) (5483S, Cell Signaling Technology, 1:2,000 dilution), anti-PPM1A (3549, Cell Signaling Technology, 1:2,000 dilution), anti-Myc (2276S, Cell Signaling Technology, 1:3,000 dilution)

(9) miR-376a Provokes Rectum Adenocarcinoma Via CTC1 Depletion-Induced Telomere DysfunctionFrontiers in cell and developmental biologyJanuary 1, 2021Liu Y, Zhao X, Wang B, Liu Z, Zhang M, Wang J, Xu C, Wang Y, Du L, Wang F, et al.promotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549. doi: 10.1038/emboj.2012.215 Frontiers in Cell and Developmental Biology | www.frontiersin.org Surovtseva,

(10) Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusionseLifeAugust 5, 2020Zhi-Jing Wu, Jia-Cheng Liu, Xin Man, Xin Gu, Ting-Yi Li, Chen Cai, Ming-Hong He, Yangyang Shao, Ning Lu, Xiaoli Xue, et al.promotes telomere duplex replication and general replication restart after fork stalling. The EMBO Journal 31:3537– 3549. DOI: https://doi.org/10.1038/emboj.2012.215, PMID: 22863775 Stewart JA. 2018. Emerging roles of CST

(11) Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic SteatohepatitisCell metabolismMay 5, 2020Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, et al.,Cell Signaling Technology,Cat#2038; RRID:AB_2169495 "Anti-PP2C-α, dil: 1/1000",Cell Signaling Technology,Cat#3549; RRID:AB_2169764 "Anti-EGFR, dil: 1/1000",Cell Signaling Technology,Cat#2232; RRID:AB_331707 "Anti-Phospho-EGFR

(12) Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere cappingPLOS GeneticsApril 14, 2020Rachel E. Langston, Dominic Palazzola, Erin Bonnell, Raymund J. Wellinger, Ted Weinertreplication and general replication restart after fork stalling. The EMBO Journal. EMBO Press; 2012; 31: 3537–3549. https://doi.org/10.1038/emboj.2012.215 PMID: 22863775 36. Kasbek C, Wang F, Price CM. Human TEN1

(13) Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)): Part BSurgical EndoscopyNovember 1, 2019R. Bittner, K. Bain, V. K. Bansal, F. Berrevoet, J. Bingener-Casey, D. Chen, J. Chen, P. Chowbey, U. A. Dietz, A. de Beaux, et al.defined. Level 5 CST can be indicated in cases of open abdomen treatment. Surgical Endoscopy (2019) 33:3511–3549 3525 Recommendaons: Grade B CST should be used to obtain fascial closure in large midline hernias. Grade

(14) Structural Analysis and Conformational Dynamics of STN1 Gene Mutations Involved in Coat Plus SyndromeFrontiers in Molecular BiosciencesJune 12, 2019Mohd. Amir, Taj Mohammad, Vijay Kumar, Mohammed F. Alajmi, Md. Tabish Rehman, Afzal Hussain, Perwez Alam, Ravins Dohare, Asimul Islam, Faizan Ahmad, et al.promotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549. doi: 10.1038/emboj.2012.215 Frontiers in Molecular Biosciences | www.frontiersin.org Conflict of

(15) Structural and functional impact of non-synonymous SNPs in the CST complex subunit TEN1: structural genomics approachBioscience ReportsMay 31, 2019Mohd. Amir, Vijay Kumar, Taj Mohammad, Ravins Dohare, Md. Tabish Rehman, Mohamed F. Alajmi, Afzal Hussain, Faizan Ahmad, Md. Imtaiyaz Hassanpromotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549, https://doi.org/10.1038/emboj.2012.215 19 Huang, C., Dai, X. and Chai, W. (2012) Human Stn1 protects

(16) Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin associationLife science allianceApril 1, 2019Wang Y, Brady KS, Caiello BP, Ackerson SM, Stewart JA.promotes telomere duplex replication and general replication restart after fork stalling. EMBO J 31: 3537–3549. doi:10.1038/emboj.2012.215 Stewart JA, Wang Y, Ackerson SM, Schuck PL (2018) Emerging roles of CST

(17) At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric SequencesGenes (Basel)February 5, 2019Anna Y. Aksenova, Sergei M. Mirkintelomere duplex replication and general replication restart after fork stalling. EMBO J. 2012, 31, 3537–3549. [CrossRef] [PubMed] 181. Wu, P.; Takai, H.; de Lange, T. Telomeric 30 overhangs derive from resection

(18) CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cellsNature communicationsJuly 19, 2018Feng X, Hsu SJ, Bhattacharjee A, Wang Y, Diao J, Price CM.promotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549 (2012). Chastain, M. et al. Human CST facilitates genome-wide RAD51 recruitment to GC-rich repetitive

(19) The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replicationScience advancesMay 1, 2018Matmati S, Vaurs M, Escandell JM, Maestroni L, Nakamura TM, Ferreira MG, Géli V, Coulon S.promotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549 (2012). A. Bhattacharjee, J. Stewart, M. Chaiken, C. M. Price, STN1 OB fold mutation alters DNA binding

(20) Human CST Prefers G-Rich but Not Necessarily Telomeric SequencesBiochemistryAugust 15, 2017Robert A. Hom, Deborah S. Wuttkepromotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31, 3537–3549. [PubMed: 22863775] (37). Gu P, Min J-N, Wang Y, Huang C, Peng T, Chai W, and Chang S (2012) CTC1 deletion

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PP2C-alpha (D18C10) XP ® Rabbit mAb

PP2C-alpha (D18C10) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PP2C-alpha (D18C10) XP ® Rabbit mAb from Cell Signaling Technology

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