Tuberin/TSC2 (D57A9) Rabbit mAb 3990S from Cell Signaling Technology

Product Specs
ItemTuberin/TSC2 (D57A9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3990S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R
TargetTuberin/TSC2
HostRabbit
NCBI Gene AliasesLAM, PPP1R160, TSC4
ClonalityMonoclonal
NCBI Full Gene NameTSC complex subunit 2
Research AreaPI3K / Akt Signaling
IsotypeIgG
CloneD57A9
Molecular Weight200

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome systemThe EMBO JournalApril 7, 2025Rameez Raja, Banhi Biswas, Rachy Abraham, Yiran Wang, Che-Yuan Chang, Ivo A Hendriks, Sara C Buch-Larsen, Hongrui Liu, Xingyi Yang, Chenyao Wang, et al.supernatant was incubated overnight with either SQSTM1/p62 (D10E10) (#7695, CST) or Rabbit IgG control (#3990, CST) antibodies at 4 °C, followed by incubation with Protein A/G PLUS-Agarose beads (Santa Cruz Biotechnology,

(2) Tuberous Sclerosis Complex cell-derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkersJournal of extracellular vesiclesJune 1, 2023Bhaoighill MN, Falcón-Pérez JM, Royo F, Tee AR, Webber JP, Dunlop EA.transferred onto PVDF membranes, blocked, then incubated with primary antibodies against TSC2 (catalogue #3990), total S6K1 (catalogue #9202), phospho‐S6K1 (T389) (catalogue #9205), pan‐Akt (catalogue #4691), phospho‐Akt

(3) Sodium Danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome and tuberous sclerosis complex-2 (TSC2)/mammalian target of rapamycin (mTOR) pathwaysAnnals of Translational MedicineOctober 1, 2022Shengzhao Hu, Yingli Chen, Shipeng Huang, Min Liu, Ying Liu, Shaofang Huang39749; CST), LC3B (cat. no. Ab192890; 1:1,000; Abcam), tuberous sclerosis complex-2 (TSC2) (cat. no. 3990; 1:1,000; CST), p-mammalian target of rapamycin (mTOR) (cat. no. Ab137133; 1:1,000; Abcam), mTOR (cat.

(4) Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast CancerCancer discoveryApril 1, 2022Chang CA, Jen J, Jiang S, Sayad A, Mer AS, Brown KR, Nixon AML, Dhabaria A, Tang KH, Venet D, et al.(T346) (5482; Cell Signaling Technology), p-AKT substrate (9614L, Cell Signaling Technology), TSC2 (3990; Cell Signaling Technology). Kinase Assays: To enrich for dephosphorylated TSC2 to use as a substrate

(5) Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptakeCell reportsMarch 15, 2022Hu SH, He XD, Nie J, Hou JL, Wu J, Liu XY, Wei Y, Tang HR, Sun WX, Zhou SX, et al.AB_2636978 phospho-TSC2(S939),Cell Signaling Technology,Cat# 3615; RRID: AB_2207796 TSC2,Cell Signaling Technology,Cat# 3990; RRID: AB_2209986 phospho-PRAS40(T246),Cell Signaling Technology,Cat# 13175; RRID: AB_2798140 PRAS40,Cell Signaling Technology

(6) The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stressSci Transl MedDecember 1, 2021Patrick M. Grierson et al.p-Hsp27 (S82) antibodies were confirmed using isotype control antibody (Cell Signaling Technology # 3990, rabbit) in formalin-fixed paraffin embedded Pa01c cell pellets expressing a scramble sequence or shRNAs

(7) Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activationDevelopmental cellMarch 22, 2021Yang W, Pang D, Chen M, Du C, Jia L, Wang L, He Y, Jiang W, Luo L, Yu Z, et al.antibody,Cell Signaling Technology,Cat#9272 Rabbit monoclonal TSC2 antibody,Cell Signaling Technology,Cat#3990 Rabbit monoclonal pAMPKα (Thr172) antibody,Cell Signaling Technology,Cat#2535 Rabbit polyclonal AMPKα

(8) Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagyThe Journal of biological chemistryJanuary 1, 2021Mimura K, Sakamaki JI, Morishita H, Kawazu M, Mano H, Mizushima N.Cell Signaling Technology), phospho-p70 S6 Kinase (T389) (9234; Cell Signaling Technology), LC3 (63), TSC2 (3990; Cell Signaling Technology), CAD (11933; Cell Signaling Technology), and DHODH (14877-1-AP; Proteintech).

(9) Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberinScience advancesJanuary 1, 2021Cheah PS, Prabhakar S, Yellen D, Beauchamp RL, Zhang X, Kasamatsu S, Bronson RT, Thiele EA, Kwiatkowski DJ, Stemmer-Rachamimov A, et al.Tween 20 and 5% nonfat dry milk, followed by an overnight incubation with primary antibody to tuberin (#3990, 1:1000 dilution, Cell Signaling Technology diluted in the same buffer at 4°C). On the next day, the

(10) PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling AnalysisMolecular cancer therapeuticsSeptember 1, 2020Lim JT, Singh N, Leuvano LA, Calvert VS, Petricoin EF, Teachey DT, Lock RB, Padi M, Kraft AS, Padi SKR.2385), anti-phospho-S6 (S240/244, Cat # 5364), anti-phospho-TSC2 (S939 Cat # 3615), anti-TSC2 (Cat # 3990), anti-PTEN (Cat # 138G6), anti-Phospho-NF-kB p65 (S536 Cat # 93H1), anti-NF-kB p65 (Cat # D14E12),

(11) Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-β Pathway Through the Circ-OXCT1/miR-136/SMAD4 AxisOncoTargets and TherapyMay 11, 2020Jianjun Liu, Xinglong Dai, Xiong Guo, Anqi Cheng, Sandrie Mariella Mac, Ziwei WangCell Signaling Technology, USA), SMAD2 (1:1000, Cell Signaling Technology), SMAD3 (1:1000, Cell Signaling 3990 Powered by TCPDF (www.tcpdf.org) submit your manuscript | www.dovepress.com DovePress Technology)

(12) Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasisLife Science AllianceFebruary 10, 2020Akira Imamoto et al.anti-phospho-AKT S473 (CST#4060), anti-pan AKT (CST#2920), anti-phospho-TSC2 T1462 (CST#3617), anti-TSC2 (CST#3990), anti-phospho-p130CAS Y247 (CST#4014), anti-p130CAS (BD 610272), anti-CRK (BD 610035), anti-CRKL (05-414;

(13) LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth controlNature cell biologyFebruary 1, 2020Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, et al.antibody (11816), anti-PRAS40 antibody (2691), anti-biotin (HRP conjugate, 5571), anti-TSC2 antibody (3990), anti-JNK2 antibody (9258), anti-CaMKII (pan) antibody (3362) and anti-CaMKIV antibody (4032) were

(14) mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulationThe Journal of clinical investigationDecember 2, 2019Asrani K, Murali S, Lam B, Na CH, Phatak P, Sood A, Kaur H, Khan Z, Noë M, Anchoori RK, et al.antibodies. The following antibodies were used: Tsc1 (catalog 6935, Cell Signaling), 1:1000; Tsc2 (catalog 3990, Cell Signaling), 1:1000; Rheb (catalog 09-247, Millipore), 1:1000; Raptor (catalog 2280, Cell Signaling),

(15) Weipiling ameliorates gastric precancerous lesions in Atp4a−/− miceBMC Complementary and Alternative MedicineDecember 1, 2019Wei Liu, Zi-ming Zhao, Yuan-liang Liu, Hua-feng Pan, Li-zhu Lin(1:1000 dilution; CST: 13879, USA), TSC1 (1:1000 dilution; CST:6935, USA), TSC2 (1:1000 dilution; CST: 3990, USA), MPC1 (1:1000 dilution; CST: 14462, USA) and β-actin (1:1000 dilution; CST: 4967, USA) antibodies.

(16) Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivityOncotargetOctober 8, 2019Woodford MR, Hughes M, Sager RA, Backe SJ, Baker-Williams AJ, Bratslavsky MS, Jacob JM, Shapiro O, Wong M, Bratslavsky G, et al.Life Sciences; ADI-CSA-335), Tsc1 1:1000 (Cell Signaling Technology (CST); 4906), Tsc2 1:1000 (CST; 3990), K-Ac 1:1000 (CST; 9441), phos-Ser 1:1000 (Sigma; P5747), phos-Thr 1:1000 (Sigma; P6623), phos-Tyr

(17) Oncogenic miR‑744 promotes prostate cancer growth through direct targeting of LKB1Oncology LettersDecember 11, 2018Minglei Zhang, Hai Li, Yun Zhang, Hongyan Li(Thr172) (1:200; cat. no. 2535), phospho-AMPKβ1 (Ser182) (1:250; cat. no. 4186) TSC2 (1:500; cat. no. 3990), phospho-TSC2 (Ser1387) (1:250; cat. no. 23402), mTOR (1:1,000; cat. no. 2983), phospho-mTOR (Ser2448)

(18) Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell deathOncogeneNovember 1, 2018Johnson CE, Dunlop EA, Seifan S, McCann HD, Hay T, Parfitt GJ, Jones AT, Giles PJ, Shen MH, Sampson JR, et al.(#11815), caspase 3 (#9662), caspase 8 (mouse speciﬁc #4927, human speciﬁc #9746), PARP (#9542), TSC2 (#3990), and β-actin (#4967) were purchased from Cell Signaling Technology (Danvers, USA). Growth arrest and

(19) Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspringMolecular MetabolismOctober 1, 2018Jessica H. Beeson, Heather L. Blackmore, Sarah K. Carr, Laura Dearden, Daniella E. Duque-GuimarÃ£es, Laura C. Kusinski, Lucas C. PantaleÃ£o, Adele G. Pinnock, Catherine E. Aiken, Dino A. Giussani, et al.were used at 1:1000 dilution and were obtained from Cell Signaling Technology (MA, USA): Tropomyosin (#3990S rabbit monoclonal), Troponin I (#4002S rabbit polyclonal), phosphorylated (Ser23/24) Troponin I (p-Troponin

(20) Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug DiscoveryEBioMedicineJuly 1, 2018Benedetti V, Brizi V, Guida P, Tomasoni S, Ciampi O, Angeli E, Valbusa U, Benigni A, Remuzzi G, Xinaris C.

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Tuberin/TSC2 (D57A9) Rabbit mAb

Tuberin/TSC2 (D57A9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Tuberin/TSC2 (D57A9) Rabbit mAb from Cell Signaling Technology

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