Fig 2: Overlapping and distinct functions of eIF3d and eIF3e(A) Diagram of a simplified eIF3 complex with only eIF3d and eIF3e labeled for clarity.(B) Outline of the experimental design of Ribo-seq and RNA-seq.(C) siRNA knockdown (KD) of eIF3d and eIF3e in MCF7-SIX1 cells, followed by western blot analysis.(D) Venn diagram of the overlapping and distinct differentially translated mRNAs after eIF3d and eIF3e KD. p values were calculated with Fisher’s exact test.(E) Heatmap of specific mRNAs that are shared or specific to eIF3d vs. eIF3e. The values are Z scores of the TE.(F) Gene set enrichment analysis for the hypoxia hallmark dataset when eIF3e and eIF3d are knocked down.